While out with Wonder Woman, Superman has been infected by the "Repulse" as part of Lex Luthor's plan to destroy Superman.
As Wonder Woman and Hawkman try to find a way to save him, Superman must remove nanobots from his body by sending them into a black hole before he gets pulled into it as well.
Though Lex Luthor plans to take advantage of the situation by trying to kill Superman.
When Uthool suddenly disappears, it turns out that Uthool has possessed Batman where he defeats Booster Gold, Wonder Woman, and Cyborg in his plot to have the Hall of Justice's core temperature break the Earth's mantle.
Upon Uthool transforming Batman into a bat monster, Superman ends up fighting Uthool in order to get him out of Batman.
As Superman gives Blue Beetle, Firestorm, and Stargirl a tour of the Fortress of Solitude, they run afoul of General Zod, Faora, and Quex-Ul who are accidentally freed from the Phantom Zone.